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ANTIBODIES THAT SPECIFICALLY BIND ALPHA-TOXIN STAPHYLOCOCCUS AUREUS, AND WAYS OF THEIR APPLICATION
专利权人:
ЭлЭлСи (US);МЕДИММЬЮН
发明人:
СЭЛЛМАН Брет (US),ТКАЧИК Христине (US),ХУА Лэй (US),ЧОВДХУРИ Партха (US),ВАРКИ Рина (US),ДАМШРОДЕР Мелисса (US),ПЭН Ли (US),ОГАНЕСЯН Вахех (US),ХИЛЛИАРД Джеймси Джонсон (US)
申请号:
RU2013141134/10
公开号:
RU2013141134A
申请日:
2012.02.07
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A purified / isolated antibody or antibody fragment, wherein the antibody or fragment immunospecifically binds to the Staphylococcus aureus alpha toxin polypeptide and contains: (a) CDR1 VH containing an amino acid sequence identical to SEQ ID NO: 7, 10, 13 or 69 or containing 1, 2 or 3 substitutions of amino acid residues in relation to them; (b) CDR2 VH containing an amino acid sequence identical to SEQ ID NO: 8, 11, 14, 17, 70 or 75 or containing 1, 2 or 3 substitutions of amino acid residues according to relation to them, and (c) CDR3 VH containing the amino acid sequence, ident primary SEQ ID NO: 9, 12, 15, 18, 16, 65, 66, 67, 71, 72, 76 or 78, or containing 1, 2 or 3 substitutions of amino acid residues with respect to them. 2. The antibody or antigen binding fragment of claim 1, wherein CDR1 VH, CDR2 VH, and CDR3 VH are represented by SEQ ID NO: 7, 8, and 9; SEQ ID NO: 10, 11 and 12; SEQ ID NO: 13, 14, and 15; SEQ ID NO: 7, 17 and 18; SEQ ID NO: 7, 8, and 16; SEQ ID NO: 7, 8, and 65; SEQ ID NO: 7, 8, and 66; SEQ ID NO 7, 8, and 67; SEQ ID NO: 7, 8, and 78; SEQ ID NO: 69, 70 and 71; SEQ ID NO: 7, 8, and 72; SEQ ID NO: 69, 75 and 71; SEQ ID NO: 69, 75 and 76 or SEQ ID NO: 69, 70 and 71.3. An isolated antibody or antigen binding fragment thereof, wherein the isolated antibody or antigen binding fragment thereof is immunospecifically associated with a Staphylococcus aureus alpha toxin polypeptide and includes: (a) VH CDR1 containing the amino acid sequence of SEQ ID NO: 7, 10, 13 or 69; (b) CDR2 VH containing the amino acid sequence of SEQ ID NO: 8, 11, 14, 17, 70 or 75; (c) CDR3 VH containing the amino acid sequence of SEQ ID NO: 9, 12, 15, 18, 16, 65, 66, 67 , 71, 72, 76 or 78; (d) CDR1 VL containing the amino acid sequence of SEQ ID NO: 1 or 4; (e) CDR2 VL containing the amino acid after the sequence of SEQ ID NO: 2, 5, 73 or 77; and (f) a CDR3 VL containing the amino acid sequence of SEQ ID NO: 3.6, 64, 68, or 74.4. Antibody or antigen binding fragment1. О
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