SUBSTITUTED CHROMENE DERIVATIVES AS SELECTIVE DUAL INHIBITORS OF PI3 DELTA AND GAMMA PROTEIN KINASES

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专利权人:

RHIZEN PHARMACEUTICALS SA

发明人:

BHAVAR, PRASHANT KASHINATH,VAKKALANKA, SWAROOP KUMAR VENKATA SATYA

申请号：

SG11201610745X

公开号：

SG11201610745XA

申请日:

2015.06.26

申请国别(地区):

SG

年份:

2017

代理人:

摘要：

The present invention relates to a selective dual delta (δ) and gamma (γ) PI3K protein kinase modulator (S)—N-(5-(4-amino-1-(1-(5-fluoro-3-(3-fluorophenyl)-4-oxo-4H-chromen-2-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl) methane sulfonamide, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of PI3K kinase mediated diseases or disorders with them.

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