The present invention provides a polynucleotide adjuvant composition and methods of use in eliciting an immune response. The present invention also provides an immunogenic composition comprising the polynucleotide adjuvant composition together with other immunogenic compositions such as an antigen (e.g., as in a vaccine). The present invention further contemplates methods of use of such adjuvant compositions, particularly in eliciting an immune response to an antigenic compound.本發明提供聚核苷酸佐劑組合物以及引發免疫反應的使用方法。本發明亦提供一種免疫原組合物,包含該聚核苷酸佐劑組合物和抗原等其他免疫原組合物(例如此二種成份位於一疫苗內)。本發明更思及這些佐劑組合物的使用方法,特別是誘導對於抗原化合物的免疫反應。