Bismuth-containing compounds, coordination polymers, methods for modulating pharmacokinetic properties of biologically active agents, and methods for treating patients
PRICE, John D.,PICCARIELLO, Thomas,OBERLENDER, Robert A.,MULHARE, Michaela E.,PALMER, Scott B.
申请号：
AU2016204061
公开号：
AU2016204061A1
申请日:
2016.06.16
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
#$%^&*AU2016204061A120160707.pdf#####BISMUTH-CONTAINING COMPOUNDS, COORDINATION POLYMERS, METHODS FOR MODULATING PHARMACOKINETIC PROPERTIES OF BIOLOGICALLY ACTIVE AGENTS, AND METHODS FOR TREATING PATIENTS ABSTRACT Bismuth-containing compounds include bismuth and a biologically active agent coordinated to the bismuth. The biologically active agent includes at least one heteroatom configured for coordination with the bismuth. Coordination polymers include a polymer matrix that contains a bismuth-containing compound. Methods for modulating a pharmacokinetic property of a biologically active agent include coordinating the biologically active agent to bismuth to form a bismuth-containing compound, and administering the bismuth-containing compound orally to a patient. Methods for treating Parkinson's disease, methods for treating hypothyroidism, methods for treating ulcerative colitis, and methods for treating cancer each include administering a bismuth-containing compound to a patient. 7R7040P 1 (CHMattr) P103435 Al J RONIAM1 o19 FIG. 1 NH2 0 0 cell m / NH2 surfaceI 0 0 bicadhesive 5-ASA adjuvant FIG. 2 cell P- 0 -NH2 surface bloadhesive 5-ASA adjuvant
