您的位置: 首页 > 农业专利 > 详情页

ANTIBODY DRUG CONJUGATES FOR ABLATING HEMATOPOIETIC STEM CELLS
专利权人:
NOVARTIS AG
发明人:
CELLITTI, Susan E.,COOKE, Michael P.,GEIERSTANGER, Bernhard Hubert,BOITANO, Anthony E.,JIN, Yunho,BURGER, Matthew,LEE-HOEFLICH, Si Tuen,UNO, Tetsuo,PHAM, HongNgoc Thi,FINNER, Catrin,TISSOT, Kath
申请号:
CR20190296
公开号:
CR20190296A
申请日:
2017.12.19
申请国别(地区):
CR
年份:
2019
代理人:
摘要:
The present invention provides an antibody copolymer, one of which is an antibody or a part of an antibody, specifically connected to a human The present invention also provides pharmaceutical ingredients, including drug antibody copolymers, and methods for developing and using these pharmaceutical ingredients to cut blood stem cells in a patient in need, Wherein an antiody or antiody fragment that specifically binds to human ckit is linked to a drug moiety,Link optimization. The present invention further provides pharmaceutical compositions comprising the antiody drug conjugates;and methods of making and using such pharmaceutical compositions for ablating hematopoietic stem cells in a patient in need there.La presente invención proporciona conjugados anticuerpo droga, donde un anticuerpo o fragmento de anticuerpo que específicamente se une a cKIT humano se conecta a un resto droga, opcionalmente a través de un ligador. La presente invención además proporciona composiciones farmacéuticas que comprenden los conjugados anticuerpo droga; y métodos para elaborar y usar dichas composiciones farmacéuticas para ablación de células madre hematopoyéticas en un paciente que lo necesitaThe present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates; and methods of making and using such pharmaceutical compositions for ablating hematopoietic stem cells in a patient in need thereof.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充