PROBLEM TO BE SOLVED: To provide a composition to improve symptoms of diabetes and its complication.SOLUTION: The composition includes an effective amount of one selected from among the group composed of Lactobacillus reuteri GMNL-89, Lactobacillus gasseri GMNL-205, and Lactobacillus reuteri GMNL-263 and a pharmacologically acceptable carrier medicine, wherein the Lactobacillus gasseri GMNL-205 and Lactobacillus reuteri GMNL-263 are a novel lactobacillus isolated strain.