Methods, systems, and related computer program products for processing and displaying computer-aided detection (CAD) information associated with medical breast x-ray images, such as breast x-ray tomosynthesis volumes and conventional x-ray mammograms, are described. An interactive graphical user interface for displaying a tomosynthesis data volume includes a display of a two-dimensional composited image having slabbed sub-images spatially localized to marked CAD findings. Graphical navigation tools for optimized CAD-assisted viewing of the data volume are described. For one preferred embodiment, CAD findings for several cases (or several individual data volumes) are selectively designated for marking such that a predetermined number of CAD findings per case (or per data volume) are marked for display across all of the cases (or data volumes). In other preferred embodiments, localized breast fibroglandular tissue density information is used together with certainty-of-finding information as a basis for selecting which candidate CAD findings to designate as marked CAD findings.
