PROCEDE DE FABRICATION D'AGREGAT DE CELLULES CONTENANT DES CELLULES NEURALES OU DES TISSUS NERVEUX ET DES TISSUS EPITHELIAUX NON NERVEUX, ET AGREGAT DE CELLULES
The present invention addresses the problem of providing a means of efficiently producing, from pluripotent stem cells, a cell mass that includes neural cells/tissue and non-neural epithelial tissue. Provided is a production method for a cell mass that includes 1) neural cells or neural tissue, and 2) non-neural epithelial tissue, said method comprising steps (1) and (2): (1) a first step in which pluripotent stem cells are suspension-cultured in the presence of a Wnt-signalling pathway inhibitor, and a cell aggregation is formed； and (2) a second step in which the aggregate obtained in the first step is suspension-cultured in the presence of a BMP-signalling pathway activator, and a cell mass that includes 1) neural cells/tissue, and 2) non-neural epithelial tissue, is obtained.
