Peter D. Kwong,Gary J. Nabel,George Shaw,William Schief,Zhi-yong Yang,Tongqing Zhou,Lei Chen,Young Do Kwon
申请号：
US12866723
公开号：
US20120034254A1
申请日:
2009.02.06
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed are antigens that include a target epitope that is defined by atomic coordinates of those amino acids of the antigen that contact an antibody of interest that specifically binds the antigen. The disclosed antigens have between about 10% and about 90% of surface exposed amino acid residues located exterior of the target epitope substituted as compared to a wild-type antigen and less than about 10% of the non-surface exposed amino acid residues substituted as compared to a wild-type antigen. Also disclosed are nucleic acids encoding these antigens and methods of producing these antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a human immunodeficiency type 1 (HIV-1) infection in a subject.
