The present invention relates to a Streptococcus pneumoniae vaccine composition and, more particularly, provides a vaccine composition comprising: (i) a capsular polysaccharide-protein conjugate； (ii) 2-phenoxyethanol (2-PE)； and (iii) formaldehyde (HCHO), and a method for preparing the same. The polyvalent Streptococcus pneumoniae vaccine composition according to the present invention comprises a polyvalent conjugate of a narrow-band polysaccharide-protein having a peculiar junction structure, and contains a combination and a content of 2-phenoxyethanol and formaldehyde optimized as described above as a preservative, and is excellent in stability and/or storage power.COPYRIGHT KIPO 2018폐렴구균 (스트렙토코커스 뉴모니애； Streptococcus pneumoniae) 백신 조성물에 관한 것으로, 보다 구체적으로, (i) 협막 다당류 (capsular polysaccharide)-단백질 접합체, (ii) 2-페녹시에탄올 (2-Phenoxyethanol, 2-PE), 및 (iii) 포름알데히드 (Formaldehyde, HCHO)를 포함하는 백신 조성물 및 이를 제조하는 방법이 제공된다.
