Julianne SMITH,Julien VALTON,Philippe DUCHATEAU,Alexandre JUILLERAT,Arvind RAJPAL,Barbra Johnson SASU
申请号：
US15546619
公开号：
US20180002427A1
申请日:
2016.01.25
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to a new generation of chimeric antigen receptors (CAR) referred to as multi-chain CARs, which are made specific to the antigen CLL1. Such CARs aim to redirect immune cell specificity and reactivity toward malignant cells expressing the tumor antigen CLL1. The alpha, beta and gamma polypeptides composing these CARs are designed to assemble in juxtamembrane position, which forms flexible architecture closer to natural receptors, that confers optimal signal transduction. The invention encompasses the polynucleotides, vectors encoding said multi-chain CAR and the isolated cells expressing them at their surface, in particularly for their use in immunotherapy. The invention opens the way to efficient adoptive immunotherapy strategies for treating cancer, especially leukemia.
