Mina E. Aikawa,Payman Amiri,Jeffrey H. Dove,Barry Haskell Levine,Christopher McBride,Teresa E. Pick,Daniel J. Poon,Savithri Ramurthy,Paul A. Renhowe,Cynthia Shafer,Darrin Stuart,Sharadha Subramanian
申请号：
US12759578
公开号：
US08592459B2
申请日:
2010.04.13
申请国别(地区):
US
年份:
2013
代理人:
摘要：
New substituted benzimidazole compounds, compositions, and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.
