COMPOSE TAXANE, ET SON PROCEDE DE PREPARATION ET SON UTILISATION

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专利权人:

LTD.;JIANGSU TASLY DIYI PHARMACEUTICAL CO.

发明人:

ZHOU, WEI,JING, YUNRONG,WANG, YONGFENG,WANG, GUOCHENG

申请号：

CA2931366

公开号：

CA2931366A1

申请日:

2014.11.21

申请国别(地区):

CA

年份:

2015

代理人:

摘要：

Provided are taxane compounds having the structure of formula I, preparation method thereof, and uses of compositions having the compounds, pharmaceutical salts and solvates thereof as active ingredients in the preparation of oral antineoplastic drugs. In the formula, R1 is -COR6, -COOR6 and -CONR7aR7b； R2 is C1-C6 alkyl, C1-C6 alkenyl, substituted hydrocarbyl, heterocyclyl, aryl or substituted aryl； R3 is -OR6, -OCOOR6, -OCOSR6 and -OCONR7aR7b； R4 is -OR6, -OCOOR6, -OCOSR6, -OCONR7aR7b, H and OH； R6 is C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, substituted hydrocarbyl, aryl or heterocyclyl； and R7a and R7b are hydrogen, hydrocarbyl, substituted hydrocarbyl or heterocyclyl.

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