Provided are humanized antibodies that selectively bind to and inhibit activated protein C without binding to or inhibiting unactivated protein C. Methods of treatment employing these antibodies are described herein.本發明提供特異地結合至活化蛋白C且抑制活化蛋白C、但不會結合至非活化蛋白C或抑制非活化蛋白C的人化抗體。本文說明採用此等抗體的治療方法。