MULLER BERNHARD K,BARLOW EVE H,HSIEH CHUNG-MING,SCHMIDIT MARTIN,LEDDY MARY R,BARDWELL PHILLIP D
申请号：
ZA201208539
公开号：
ZA201208539B
申请日:
2012.11.13
申请国别(地区):
ZA
年份:
2015
代理人:
摘要：
The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or portions thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but not limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.
