ＵＳＰＡ２蛋白質構築體及其用途农业专利-农业学术服务平台

发明人:: BLAIS, NORMAND,贝雷斯　诺曼德,貝雷斯　諾曼德,CASTADO, CINDY,卡士塔多　辛蒂,CHOMEZ, PATRICK,秋梅兹　派崔克,秋梅茲　派崔克,DEWERCHIN, MARIANNE,迪威钦　玛莉安,迪威欽　瑪莉安,贝雷斯诺曼德,貝雷斯諾曼德,卡士塔多辛蒂,秋梅兹派崔克,秋梅茲派崔克,迪威钦玛莉安,迪威欽瑪莉安

摘要：: The present invention relates to compositions comprising Moraxella catarrhalis (M. catarrhalis) Ubiquitous surface protein A2 (UspA2). More particularly, the present application relates to UspA2 protein constructs and immunogenic compositions comprising the constructs, vaccines comprising such immunogenic compositions and therapeutic uses of the same. The invention further relates to compositions comprising UspA2 in combination with at least one antigen from Haemophilus influenzae, immunogenic compositions comprising the antigens, vaccines comprising such immunogenic compositions and therapeutic uses of the same.本發明係關於包含卡他莫拉菌(Moraxella catarrhalis/M.catarrhalis)普遍存在的表面蛋白A2(UspA2)之組合物。更特定言之，本申請案係關於UspA2蛋白質構築體及包含該等構築體之免疫原性組合物、包含該等免疫原性組合物之疫苗及其治療用途。本發明進一步係關於包含UspA2與至少一種來自流感嗜血桿菌(Haemophilus influenzae)之抗原組合之組合物、包含該等抗原之免疫原性組合物、包含該等免疫原性組合物之疫苗及其治療用途。