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5-Benzylisoquinoline derivatives for the treatment of cardiovascular diseases
专利权人:
Les Laboratoires Servier
发明人:
CHIMENTI, Stefano,COURCHAY, Christine,DESSINGES, Aimée,GELLIBERT, Françoise,GOUMENT, Bertrand,KONNERT, Marc,PEGLION, Jean-Louis,POITEVIN, Christophe,VILAINE, Jean-Paul,VILLENEUVE, Nicole
申请号:
ES15709289
公开号:
ES2659885T3
申请日:
2015.02.20
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
Compound of formula (I): ** (See formula) ** where: - X represents a group -C (>; = O), -CH (OH) - or -CH2-, - Ri1 represents a hydrogen atom or a hydroxyl group, it being understood that the compounds of formula (I) where Ri1 represents a hydroxyl group can be represented in the following tautomeric form: ** (See formula) ** - Ri2 and Ri3, identical or different, represent in each case an atom of hydrogen, a (C1-C6) alkyl group or a halogen atom, - Ri6, Ri7 and Ri8, identical or different, in each case represent a hydrogen or halogen atom, - Ra1 and Ra5, identical or different, represent in each case a hydrogen or halogen atom, a -O-C1-C6 alkyl group or a C1-C6 alkyl group, - Ra2 represents a hydrogen or halogen atom, a hydroxyl group, a group - O (C1-C6) alkyl, a (C1-C6) alkyl group, a nitrogen heterocycle of 3 to 7 links or a group -O- (CH2) m-NR'R '', - Ra3 represents a hydrogen atom , a group - O (C1-C6) alkyl, a (C1-C6) alkyl group, a nitrogen heterocycle of 3 to 7 links or a group -CRy1Ry2NH (Ry3), - Ra4 represents a hydrogen or halogen atom, a group - O (C1-C6) alkyl, a (C1-C6) alkyl group, or a -CRy1Ry2NH (Ry3) group, it being understood that: - Ra1, Ra2, Ra3, Ra4 and Ra5 cannot simultaneously represent a hydrogen atom, - Ra3 and Ra4 cannot simultaneously represent a group -CRy1Ry2NH (Ry3), - Ra1 and Ra2 can form, together with the carbon atoms that carry them, a heterocycle of 4 to 7 links selected from tetrahydrofuran, 1,4-dioxane, tetrahydropyran , tetrahydro-2H-pyran-4-amine or 1- (tetrahydro-2H-pyran-4-yl) methanoamine, and - Ra2 and Ra3 can form, together with the carbon atoms that carry them, a cyclic hydrocarbon of 4 to 7 links selected from cyclopentane, cyclopentanoamine, N-cyclopentylglisinamide or 1-methylcyclopentanoamine, - m is an integer whose value is set at 1, 2 or 3, - R 'and R' ', id Ethical or different, in each case they represent groups (C1-C6) alkyl, or together with the nitrogen atom that carries them, a heterocycle of 3 to 7 link
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