A universal fluid system connector creates an airtight seal between a variety of smoke evacuation system receptacles and various hoses. The universal connector includes a body, a seal having a plurality of radially extending flexible fins, and a swivel. A plurality of fins on the seal are disposed along the length of the body with the outer edges of the fins forming a frustoconical shape. The fins also include one or more flexion zones of various stiffness and one or more flexible fin extensions. The fins deform against the inner wall of a receptacle and form an airtight friction fit between the universal connector and the receptacle, regardless of the taper angle, size, threads, or other features of the receptacle. The swivel facilitates rotational movement between the universal fluid system connector and an associated hose.