William J. SMITH;John E. MACNAIR;Cecilia GIOVARELLI;Merck Sharp &； Dohme Corp.;Michael A. WINTERS;Sheng-Ching WANG;Thomas SVAB
发明人:
John E. MacNair,Michael A. Winters,Thomas Svab,Sheng-Ching Wang,William J. Smith,Cecilia Giovarelli
申请号：
US16487621
公开号：
US20200061179A1
申请日:
2018.02.20
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which polysaccharides obtained from bacterial capsules are conjugated to diphtheria toxin fragment B (DTFB) or a variant thereof. The immunogenic compositions may be multivalent pneumococcal polysaccharide conjugate compositions in which polysaccharides from one or more Streptococcus pneumoniae serotypes are conjugated to diphtheria toxin fragment B (DTFB) and, optionally, additional polysaccharides from one or more different Streptococcus pneumoniae serotypes are conjugated to one or more other carrier proteins.
