Barry Victor Lloyd Potter;Christian Bubert;Lok Wai Lawrence Woo;Paul Michael Wood;Atul Purohit;Aurélien Putey
发明人:
Lok Wai Lawrence Woo,Christian Bubert,Paul Michael Wood,Aurélien Putey,Atul Purohit,Barry Victor Lloyd Potter
申请号：
US13392206
公开号：
US20120238550A1
申请日:
2010.08.23
申请国别(地区):
US
年份:
2012
代理人:
摘要：
There is provided a compound of formula Iwherein Z is selected from N and CR22, wherein R22 is H or a bond with D；wherein D is selected from a bond, C═O, and linear or branched hydrocarbon groups having a carbon chain of from 1 to 6 carbon atoms, wherein the carbon chain optionally contains an oxy group (═O), an ether (—O—) or thioether (—S—) link,wherein R1 is selected from: triazolyl, imidazolyl, pyrimidinyl radicalwherein each of R2 to R6 is independently selected from —H, NO2, halo, —CN, —N[(C═O)0-1R12][(C═O)0-1R13] and —(CH2)0-1R14,or two adjacent groups of R2 to R6, together with the carbon atoms to which they are attached, form a ring,wherein at least one of R2 to R6 is —CN,wherein(i) at least one of R2 to R6 is —(CH2)0-1R14, or(ii) at least one of R2 to R6 is —N[(C═O)0-1R12][(C═O)0-1R13], or(iii) at least two adjacent groups of R2 to R6 together with the carbon atoms to which they are attached, form a ring, or(iv) at least one of R2 to R6 is —(CH2)0-1—O—R′14,wherein R12 and R13 are independently selected from H, linear or branched hydrocarbon groups having a carbon chain of from 1 to 10 carbon atoms,or together with the atoms to which they are attached, may form a mono or bicyclic ring having from 5 to 14 ring memberswherein R14 is selected from:aliphatic ring systemsunsubstituted or substituted monocyclic aliphatic heterocycles；unsubstituted or substituted heteroaryl radical, andunsubstituted or substituted phenyl group；the group of formulawherein t is 1 or 2wherein R′14 is a unsubstituted or substituted phenyl group；wherein each of R7 to R11 is independently selected from —H, NO2, halo, —O—(C1-C6)haloalkyl, (C1-C6)haloalkyl, (C1-C6)alkyl, —CN, —OH, —OPh, —OBn, -Ph, —OSO2NR15R16, —SO2R26, —SO2NR27R28, —O—(C1-C6)alkyl, —(C═O)0-1NR29R30 and —CO(O)0-1R31；wherein R15 and R16 are independently selected from H, alkyl, cycloalkyl, alkenyl, acyl and aryl, or combinations thereof, or together represent alkylene, wherein the
