Disclosed is a pharmaceutical composition of ibuprofen for injection comprising an aqueous solution of ibuprofen and trometamol (tris / tris(hydroxymethyl)aminomethane / 2-amino-2-hydroxymethyl-propane-1,3-diol), wherein the concentration of ibuprofen is between 2 and 6 mg/ml, the concentration of trometamol is between 1.8 and 5.8 mg/ml, and the pH is between 7.0 and 9.5, wherein the composition can be sterilised by heat by autoclaving at a temperature between 110°C and 130°C for a time between 2 and 190 minutes, and wherein the composition is for use in the treatment of pain, inflammation or fever.
