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Pharmaceutical composition of ibuprofen for injection
专利权人:
СПЭЙН ФАРМА; С.А. (ES)
发明人:
ОРТУСАР АНДЕЧАГА Игнасио (ES),ОРТУСАР ГУТЬЕРРЕС Марио (ES)
申请号:
RU2012154628/15
公开号:
RU2012154628A
申请日:
2011.05.18
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. The pharmaceutical composition of ibuprofen for injection, containing an aqueous solution of ibuprofen and trometamol, in which the concentration of ibuprofen is from 2 to 6 mg / ml, the concentration of trometamol is from 1.8 to 5.8 mg / ml, and the pH value is from 7 , 0 to 9.5.2. The ibuprofen pharmaceutical composition for injection according to claim 1, wherein the ibuprofen concentration is about 4 mg / ml. A pharmaceutical composition according to claim 1 or 2, wherein the concentration of trometamol is approximately 3.8 mg / ml. The pharmaceutical composition according to claim 1, which is heat sterilized by autoclaving at a temperature of from 110 ° C to 130 ° C for a period of time from 2 to 190 minutes. The pharmaceutical composition of claim 4, wherein the composition is heat sterilizable by autoclaving at 121 ° C for 15 minutes. The ibuprofen pharmaceutical composition for injection according to claim 1, wherein the composition is in glass containers and has a pH value of 7.0 to 9.5.7. The ibuprofen pharmaceutical composition for injection according to claim 1, wherein the composition is in polyethylene containers and has a pH value of 7.0 to 9.0.8. The ibuprofen pharmaceutical composition for injection according to claim 1, wherein the composition is in polypropylene containers and has a pH value of 7.5 to 9.0.9. The ibuprofen pharmaceutical composition for injection according to claim 1, wherein the composition is in PVC containers and has a pH value of 8.0 to 9.0.10. The pharmaceutical composition according to claim 1, which has a pH value of about 8.5.11. The pharmaceutical composition according to claim 1, additionally containing salt in an amount necessary to give the composition an osmolality equal to example1. Фармацевтическая композиция ибупрофена для инъекции, содержащая водный раствор ибупрофена и трометамол, в которой концентрация ибупрофена составляет от 2 до 6 мг/мл, концентрация трометамола составляет от 1,8 до 5,8 мг/мл, и значение pH
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