Detection systems and methods configured to scan and interpret a suspected infection at in vivo biological target site, comprising emitting excitation light selected to elicit fluorescent light from a suspected infection at the target site； sensing fluorescent light emanating from the target site elicited by such excitation light； sensing heat levels above ambient body temperature emanating from the target site； and then based at least in part on the sensed fluorescent light and the heat levels, determining a probability whether the target site comprises an infection.
