PROBLEM TO BE SOLVED: To provide a medicine, quasi-drug, or food, which is useful for improving knee pain, or a material or preparation that can be compounded with any of them.SOLUTION: According to the present invention, there is provided a knee pain remedy comprising as an active ingredient a milk fat globule membrane containing 5 to 100% by mass of phospholipid, preferably 1 to 50% by mass of sphingomyelin. Preferably, the remedy further comprises as an active ingredient glucosamine or a salt thereof. Here, preferably, 10 to 1500 mg of the sphingomyelin per adult per day is administered or ingested. Furthermore, 10 to 20000 mg of glucosamine per adult per day is administered or ingested.SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】膝の痛みの改善に有用な医薬品、医薬部外品又は食品、或いはこれらに配合可能な素材又は製剤の提供。【解決手段】乳脂肪球皮膜を有効成分とする膝の痛み改善剤において、乳脂肪球皮膜がリン脂質を5~100質量%含有すること、好ましくは乳脂肪球皮膜が、スフィンゴミエリンを1~50質量%含有し、更にグルコサミン又はその塩を有効成分として含有する経口投与用の固形製剤が好ましい。成人1人当り、1日にスフィンゴミエリンを10~1500mg投与又は摂取することが好ましく、更にグルコサミンを1日当り、10~20000mg投与又は摂取することが好ましい、膝の痛み改善剤。【選択図】なし