#$%^&*AU2018203501B220191121.pdf#####ABSTRACT The present invention discloses a novel use of a pharmaceutical composition in the preparation of a medicament in the treatment of opioid-induced tolerance and addiction, in particular to the use of ACl inhibitor NBOO1 and AC1&8 mixed inhibitors NBO10 5 and NBO11 in the preparation of a medicament in the treatment of opioid-induced tolerance and addiction.A nxietyrelated UP 2502001500o0 Drug treatment Fig.2 Motpine tolerance test 50, 40. Day I Day 5 Daoy 7 Fig.3 2/4