HENRY, STEPHEN MICHEAL,KOMARRAJU, VENKATA SARVANI,WILLIAMS, ELEANOR CHRISTINE
申请号：
NZ57768910
公开号：
NZ577689A
申请日:
2010.09.10
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is a method for determining the likelihood of infection of a subject with Treponema palladium comprising the steps of: Contacting a sample of the plasma or serum of the subject with a suspension of cells modified to incorporate a water soluble peptide-lipid construct of the structure F-S-L or L-S-F to provide a mixture Incubating the mixture for a time and at a temperature sufficient to allow agglutination and Determining the degree of agglutination of the cells in the mixture where: F is a peptide comprising the sequence: AlaSerGlyAlaLysGluGluAlaGluLysLysAlaAlaGluGlnArgAlaLeuLeu (SEQID NO: 3) S is a spacer covalently linking F to L L is a lipid selected from the group consisting of diacyl- and dialkyl-glycerophospholipids and the degree of agglutination indicates the likelihood of infection of the subject.
