The present invention relates to the novel fused pyrimidine derivatives to tyrosine kinase with inhibitory activity, and are prevented as active constituent with what comprising the derivative or treating cancer, tumour, the pharmaceutical composition of diseases associated with inflammation, autoimmune disease or immune-mediated disease.本發明涉及對酪氨酸激酶具有抑制活性的新型稠合嘧啶衍生物,以及包含所述衍生物作爲活性成分的用於預防或治療癌症、腫瘤、炎症性疾病、自身免疫性疾病或免疫介導性疾病的藥物組合物。