EKBLAD, Caroline,GUNNERIUSSON, Elin,LINDBORG, Malin,ABRAHMSEN, Lars,LÖFBLOM, John,GRÄSLUND, Torbjörn,SEIJSING, Johan
申请号：
ES14710879
公开号：
ES2660912T3
申请日:
2014.03.17
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
The FcRn binding polypeptide, comprising a BM motif of FcRn binding, motif consisting of the amino acid sequence EX2 X3 X4 AX6 X7 EIR WLPNLX16X17 X18 QR X21 AFIX25 X26LX28 X29 where, independently of each other, X2 is selected from A , D, E, F, H, I, K, L, N, Q, R, S, T, V, W and Y； X3 is selected from A, D, E, F, G, H, I, K, L, M, N, Q, R, S, T, V, W and Y； X4 is selected from A, D, E, F, G, H, I, K, L, N, Q, R, S, T, V, W and Y； X6 is selected from A, E, F, G, H, I, K, Q, R, S and V； X7 is selected from A, F, H, K, N, Q, R, S and V； X16 is selected from N and T； X17 is selected from F, W and Y； X18 is selected from A, D, E and N； X21 is selected from A, S, V and W； X25 is selected from D, E, G, H, I, K, L, N, Q, R, S, T, V, W and Y； X26 is selected between K and S； X28 is selected from A, D, E, F, H, I, K, L, N, Q, R, S, T, V, W and Y； and X29 is selected between D and R.El polipéptido de unión a FcRn, que comprende un motivo BM de unión a FcRn, motivo que consiste en la secuencia de aminoácidos EX2 X3 X4 AX6 X7 EIR WLPNLX16X17 X18 QR X21 AFIX25 X26LX28 X29 en donde, independientemente entre sí, X2 se selecciona entre A, D, E, F, H, I, K, L, N, Q, R, S, T, V, W e Y； X3 se selecciona entre A, D, E, F, G, H, I, K, L, M, N, Q, R, S, T, V, W e Y； X4 se selecciona entre A, D, E, F, G, H, I, K, L, N, Q, R, S, T, V, W e Y； X6 se selecciona entre A, E, F, G, H, I, K, Q, R, S y V； X7 se selecciona entre A, F, H, K, N, Q, R, S y V； X16 se selecciona entre N y T； X17 se selecciona entre F, W e Y； X18 se selecciona entre A, D, E y N； X21 se selecciona entre A, S, V y W； X25 se selecciona entre D, E, G, H, I, K, L, N, Q, R, S, T, V, W e Y； X26 se selecciona entre K y S； X28 se selecciona entre A, D, E, F, H, I, K, L, N, Q, R, S, T, V, W e Y； y X29 se selecciona entre D y R.
