Caged platinum nanoclusters for anticancer chemotherapeutics

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专利权人:

National Health Research Institutes

发明人:

Lin, Shu-Yi

申请号：

AU2014219129

公开号：

AU2014219129B2

申请日:

2014.02.18

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

A caged platinum nanocluster complex is disclosed. The complex comprises (a) an amine-terminated dendrimer； and (b) a platinum nanocluster comprising platinum oxides, the platinum nanocluster being confined inside of the amine-terminated dendrimer. The complex exhibits cytotoxicity to cancer cells. A double-caged platinum nanocluster complex is also disclosed, which comprises polyethylene glycol (PEG) coated on the surface of a dendrimer caged platinum nanocluster complex. The double-caged caged platinum nanocluster complex comprises pH-sensitive bonds on the surface thereof. Also disclosed are methods of preparing and using the same.

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