Reducing the viral and microbial load of solid material-containing biological extract, comprises (a) providing the solid materials-containing biological extract comprising at least a biologically active substance consist of enzymes, proteins and/or peptides and (b) subjecting the extract to a high pressure treatment. The biological activity of the solid material-containing biological extract after the high pressure treatment corresponds to at least 50% of the biological activity of the solid material-containing biological extract before the high pressure treatment. An independent claim is included for is included for a solid material-containing biological extract obtained by the above method. The germ load of the extract is less than 500 Colony Forming Unit (CFU)/g. ACTIVITY : Anabolic. No biological data given. MECHANISM OF ACTION : None given.