An exoscope with enhanced depth of field imaging is provided. The exoscopeincludesfirst and second sets of optical devices, the first set having a fixed imageplane, thesecond set having a variable image plane adjacent the fixed image plane of thefirst set.The second set includes at least one variable device configured to change theposition ofthe variable image plane. A beamsplitter splits light from a combined opticalpath of thefirst and second set to respective image devices of the first and second setof opticaldevices. A controller controls the at least one variable device to change theposition of thevariable image plane relative to the fixed image plane, combines imagesacquired by therespective image devices, and controls a display device to render a combinedimage.