The present invention relates to a method for purifying lubiprostone in high purity and high yield by a simple process. To this end, the method includes the following steps: obtaining a lubiprostone solution by dissolving lubiprostone in a polar solvent adding isooctane into the lubiprostone solution and acquiring a solid product after cooling and filtering the isooctane-added solution.COPYRIGHT KIPO 2016본 발명은 고순도의 루비프로스톤을 간단한 공정에 의해 고수율로 정제하는 방법에 관한 것이다.