Maureen D. O'Connor-McCourt,Traian Sulea,John C. Zwaagstra,Jason Baardsnes,Maureen D. OConnor-McCourt
申请号：
US13654703
公开号：
US08734760B2
申请日:
2012.10.18
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention provides multivalent ligand binding agents (traps) for members of the TGF-β superfamily and polypeptide linkers and methods for making and using such constructs. The traps may be used as therapeutic or diagnostic (imaging or non-imaging) agents for diseases/disorders caused by over-production/activity of the target ligand. In an embodiment of the invention there is provided a multivalent binding agent with affinity for a member of the TGF-β superfamily, the agent having the general structure I:(<；bd1>；-linker1)k-[{<；bd1>；-linker2-<；bd2>；-linker3f-}n-(<；bd3>；)m-(linker4-<；bd4>；)d]h,where:n and h are independently greater than or equal to 1；d, f, m and k are independently equal to or greater than zero；bd's are polypeptide binding domains having an affinity for the same member of the TGF-β superfamily； and,linkers are unstructured polypeptide sequences.
