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Novel Polymer Derivatives, And Novel Polymer Derivative Imaging Probe Using Same
专利权人:
Nippon Kayaku Kabushiki Kaisha
发明人:
Keiichirou Yamamoto,Yuki Kawano
申请号:
US16319636
公开号:
US20190307905A1
申请日:
2017.07.21
申请国别(地区):
US
年份:
2019
代理人:
摘要:
Provided are a block copolymer having an enhanced effect of imaging the interior of a tumor compared to known block copolymers and imaging probes using the known block copolymers; and an imaging probe using the block copolymer. Specifically, for the purpose of enhancing penetrability into a diseased target tissue and efficiently enhancing an imaging effect compared to known block copolymers and imaging probes using the known block copolymers, disclosed is a block copolymer in which a hydrophilic polymer segment containing a polyethylene glycol chain is linked to a hydrophobic polymer segment containing a polyamino acid chain having a signal group and optionally a hydrophobic substituent in a side chain, wherein the main chain polymer combining the polyethylene glycol chain and the polyamino acid chain has an average molecular weight of not less than 2 kDa and not more than 10 kDa, and the mass content percentage of the signal group and the optional hydrophobic substituent is not less than 5% by mass and not more than 50% by mass; and also disclosed is a composition including the block copolymer.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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