Use of Polyacetylenic Glycosides for Suppression of Granulocytic Myeloid-derived Suppressor Cell Activities and Tumor Metastasis

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专利权人:

发明人:

YANG, NING-SUN,杨宁荪,楊寧蓀,WEI, WEN-CHI,魏纹祈,魏紋祈,LIN, SHENG-YEN,林圣晏,林聖晏,HSIAO, PEI-WEN,萧培文,蕭培文,CHEN, YET-RAN,陈逸然,陳逸然

申请号：

TW104141611

公开号：

TW201632195A

申请日:

2015.12.10

申请国别(地区):

TW

年份:

2016

代理人:

摘要：

A pharmacological composition for use in inhibiting differentiation, functional activities, and population of granulocytic myeloid-derived suppressor cells (gMDSCs) and/or suppressing, tumor metastasis in a subject in need thereof is disclosed. The composition comprises a therapeutically effective amount ofBidens pilosaextract, or more than one polyacetylenic compounds purified or isolated from theB. pilosaextract, and a pharmaceutically acceptable carrier.本發明係揭示一種醫藥組合物,在有需要的個體中抑制顆粒球骨髓來源抑制細胞(gMDSCs)的分化、功能活性以及細胞群體及/或抑制腫瘤轉移的用途。該組合物包含治療有效劑量的大花咸豐草萃取物,或超過一個由大花咸豐草萃取物分離而得的聚乙炔化合物,以及藥學上可接受載體。

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