Salt forms and polymorphs of (R)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl) acetamido) pyridazin-3-yl)-2-fluorobutyl)-N-methyl-1H-1,2,3-triazole-4-carboxamide

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专利权人:

the University of Texas System;Board of Regents

发明人:

Jones, Philip,Soth, Michael J.,Burke, Jason B.,Le, Kang,Liu, Gang

申请号：

AU2016378746

公开号：

AU2016378746A1

申请日:

2016.12.21

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

Disclosed herein is the compound (R)-l-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6- methylpyridin-2-yl)acetamido) pyridazin-3-yl)-2-fluorobutyl)-N-methyl-lH-l,2,3-triazole-4- carboxamide, and salt forms and polymorphs thereof demonstrating improved exposure after oral dosing. Methods of inhibition GLSl activity in a human or animal subject are also provided.

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