SALT FORMS AND POLYMORPHS OF (R)-1-(4-(6-(2-(4-(3,3-DIFLUOROCYCLOBUTOXY)-6-METHYLPYRIDIN-2-YL) ACETAMIDO) PYRIDAZIN-3-YL)-2-FLUOROBUTYL)-N-METHYL-1H-1,2,3-TRIAZOLE-4-CARBOXAMIDE

• 收藏
• 分享

专利权人:

THE UNIVERSITY OF TEXAS SYSTEM;BOARD OF REGENTS

发明人:

JONES, Philip,SOTH, Michael,BURKE, Jason,LE, Kang,LIU, Gang

申请号：

SG11201804664X

公开号：

SG11201804664XA

申请日:

2016.12.21

申请国别(地区):

SG

年份:

2018

代理人:

摘要：

Disclosed herein is the compound (R)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl)acetamido)pyridazin-3-yl)-2-fluorobutyl)-N-methyl-1H-1,2,3-triazole-4-carboxamide, and salt forms and polymorphs thereof demonstrating improved exposure after oral dosing. Methods of inhibition GLS1 activity in a human or animal subject are also provided.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/