Cosmetic use of hesperidin (I) or its derivatives in combination with at least a microorganism (probiotic), one of its fractions or metabolites, as an agent to prevent reduction of barrier function of skin, strengthen barrier function of skin, and/or strengthen protection of skin against external aggression, is claimed. ACTIVITY : Dermatological; Tranquilizer; Antipruritic; Nootropic. MECHANISM OF ACTION : None given.