Общество с ограниченной ответственностью "Международный Биотехнологический Центр "Генериум" (RU)
发明人:
Шамонов Николай Алексеевич (RU),Аббасова Светлана Георгиевна (RU)
申请号：
RU2018113706
公开号：
RU2018113706A
申请日:
2018.04.16
申请国别(地区):
RU
年份:
2019
代理人:
摘要：
The invention relates to the field of biotechnology, specifically to the problem of creating stable highly concentrated aqueous compositions of a medicinal preparation for intravitreal injections having a prolonged action. A stable aqueous pharmaceutical composition is proposed, comprising ranibizumab in a concentration of 100-300 mg/ml, which provides improved pharmacokinetic properties of a preparation upon intravitreal administration. The preparation is stable for 5 years at a temperature of +2-8ºС. The invention can be used in the pharmaceutical industry, specifically in the creation of a medicinal preparation for treating: the wet form of age-related macular degeneration in adults (ARMD)； a reduction in visual acuity with diabetic macular oedema； a reduction in visual acuity as a consequence of macular oedema caused by retinal vein occlusion (of the central retinal vein or of branches thereof)； and a reduction in visual acuity caused by choroidal neovascularization resulting from pathological myopia.
