CHANDA, ARANI,CHOI, HYEONG-WOOK,SANDERS, KRISTEN,MATHIEU, STEVEN,KUNTZ, KEVIN W.
申请号：
PE0005062016
公开号：
PE12732016A1
申请日:
2014.10.15
申请国别(地区):
PE
年份:
2016
代理人:
摘要：
The present Invention relates to a Polymorph C monohydrochloride (N - (4,6 - dimethyl - 2 - oxo - 1.2 - dihidropiridin - 3 - yl) methyl) - 5 - (Ethyl (Tetrahydro - 2H - piran - 4-yl) amino) - 4 - methyl - 4 - (morfolinometil) - [1,1 - biphenyl] - 3 - carboxamide where the Polymorph exhibits a pattern of x-ray diffraction Powder Q EU has at least 10 characteristic Peaks expressed in degrees of Angle 2 Theta (+ \/ - 0.2), Selected 10.08, 13, 16.58, 17.12, 17.53, 18.34, 18.66, 2050, 21.14, 22.30, 22.22, 23.46, 26.22, 26.60, 27.72 and 30.30. It also relates to a preparation method and a composition for treatment. This Compound Inhibits the activity of Histone METHYLTRANSFERASe Ezh2 as being useful in the treatment of breast cancer, non Hodgkins Lymphoma or b-cell lymphomaLa presente invencion se refiere a un polimorfo C de monohidrocloruro de N-((4,6-dimetil-2-oxo-1,2-dihidropiridin-3-il)metil)-5-(etil(tetrahidro-2H-piran-4-il)amino)-4-metil-4’-(morfolinometil)-[1,1’-bifenil]-3-carboxamida donde el polimorfo exhibe un patron de difraccion de rayos X del polvo que tiene al menos diez picos caracteristicos expresados en grados 2-theta (+/- 0.2), seleccionados de 10.08, 10.94, 16.58, 17.12, 17.53, 18.34, 18.66, 20.50, 21.14, 21.92, 22.22, 23.46, 26.22, 26.60, 27.72 y 30.30. Tambien se refiere a un metodo de preparacion, tratamiento y una composicion. Dicho compuesto inhibe la actividad como histona metiltransferasa de EZH2 siendo util en el tratamiento de cancer de mama, linfoma no hodgkiniano o linfoma de celulas B
