A bone implant comprises an active agent on at least a portionthereof. The active agent is locally deliverable to bone proximate theimplant in at least a two-phased release scheme. A first phase rapidlyreleases a first quantity of the active agent, and at least a second phasegradually releases a second quantity of the active agent, whereby boneformation stimulated by the active agent is modulated. In one embodiment,a porous implant comprises a porous portion coated with a calciumphosphate compound and which is contacted with a bisphosphonatecompound to form a bisphosphonate layer chemically bound to the calciumphosphate at the surface of the porous portion and to form bisphosphonatemolecules being non-chemically attached inside the pores of the porousportion. The non-chemically attached bisphosphonate molecules arereleased in the subject at a rate greater than that of the chemically boundbisphosphonate layer.
