The Board of Trustees of the University of Illinois
发明人:
Sanders, John M.,Song, Yongcheng,Oldfield, Eric,Zhang, Yonghui
申请号：
AU2007226964
公开号：
AU2007226964B2
申请日:
2007.03.16
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The invention provides, inter alia, novel bisphosphonate compounds and methodsof making and using. In embodiments, the invention provides compounds and methodsin connection with research and therapeutic applications, e.g., for tumor cellgrowth inhibition, activation of gammadelta T cells, inhibition of farnesyldiphosphate(FPPS) and/or undecaprenyldiphosphate synthase enzymes, bone resorptiondiseases, cancer, immune disorders, immunotherapy, and infectious diseases.In regards to certain embodiments, a surprising advance has been the recognitionthat certain structural features can significantly enhance the activity ofthe compounds. For example, the presence of particular cationic species e.g.,phosphonium, sulfonium, and arsonium moieties can contribute to desirablefunctional activity when positioned near a bisphosphonate moiety. In otherembodiments of non-nitrogen containing bisphosphonates, terphenyl and benzylbisphosphonate compounds and methods are provided. Further variations arealso provided.
