PROBLEM TO BE SOLVED: To provide a vaccine which can be prepared without using an expression vector, and has excellent therapeutic or preventive effects, and also an active ingredient used in the same.SOLUTION: The present invention provides an immunological non-self cell-MRP8 molecule complex composed of an immunological non-self cell and an isolated MRP8 molecule, wherein the MRP8 molecule is bound to a TLR4 which has been expressed on the surface of a cell other than the immunological non-self cell with the MRP8 molecule being bound to the surface of the immunological non-self cell, and the MRP8 molecule is also bound to the surface of the immunological non-self cell so as to stimulate the cell through the TLR4. A composition and a vaccine each containing the complex are also provided.COPYRIGHT: (C)2015,JPO&INPIT【課題】発現ベクターを用いることなく調製することができ、優れた治療又は予防効果を有するワクチン等を提供すること、及びそれに用いられる有効成分を提供すること。【解決手段】本発明は、免疫学的非自己細胞及び単離されたMRP8分子を含む、免疫学的非自己細胞-MRP8分子複合体であって、MRP8分子が、免疫学的非自己細胞の表面上に結合した状態で、該免疫学的非自己細胞以外の細胞の表面上に発現したTLR4に結合し、且つ当該TLR4を介して当該細胞を刺激し得るように、該免疫学的非自己細胞の表面上に結合している、複合体、該複合体を含む組成物及びワクチンを提供する。【選択図】なし
