ЛАЙФ ЭНД БРЭЙН ГМБХ (DE);РАЙНИШЕ ФРИДРИХ-ВИЛЬХЕЛЬМС УНИВЕРСИТЕТ (DE)
发明人:
ШЕФФЛЕР Бьерн (DE),ГЛАС Мартин (DE)
申请号：
RU2015107753
公开号：
RU2015107753A
申请日:
2013.08.06
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. The use of a cytostatic compound according to Formula I, II or III where A is carbonyl, methylene, hydroxymethinyl, alkoxymethinyl, aminomethinyl, oxime, hydrazine, arylhydrazine or semicarbazone； B, if available, is CRR, O, S or NR； R, R, R, R, R, and R are independently hydrogen； hydroxyl, alkoxy； halogen or C 1-6 alkyl； R and R are independently halogen, hydroxyl or hydrogen, R, if present, is hydroxyl, phosphate, hydrogen, halogen, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, alkoxy, alkylthio or amino； R, if present represents hydrogen or C 1-6 alkyl； R 1 represents nitro, hydrogen, hydroxyl, amino, halogen, alkyl, alkenyl, alkynyl or aryl； and R, R, R and R, if present, independently represent hydrogen, hydroxyl, halogen, alkyl, alkenyl, alkynyl, cycloalkyl or aryl； R and R, if present, independently represent hydrogen, hydroxyl, halogen, alkyl, alkenyl, alkynyl, cycloalkyl or aryl； and R, if present, is hydrogen or C 1-6 alkyl； or a salt thereof； and an alkylating compound for the manufacture of a medicament for the treatment of a solid tumor. 2. The use of claim 1, wherein the alkylating compound is an O-alkylating agent. The use according to claim 1 or 2, wherein the alkylating compound has a structure according to formula IV where X and Y are independently carbonyl, methylene, hydroxymethinyl, alkoxymethinyl, aminomethinyl, oxime, hydrazine, arylhydrazine or semicarbazone； R is hydrogen, alkyl, alkoxy, alkenyl alkynyl, cycloalkyl or aryl； and R is amino, hydrogen, hydroxyl or halogen； or a salt thereof. 4. The use of claim 1, wherein the cytostatic compound is niclosamide. 5. The application of claim 1 or 4, where1. Применение цитостатического соединения, соответствующего формуле I, II или IIIгдеA представляет собой карбонил, метилен, гидроксиметинил, алкоксиметинил, аминометинил, оксим, гидразин, арилгидразин или семикарбазон；B, если имеется, представляет собой CRR, O, S или NR；R, R, R, R, Rи Rнезависимо представляют собой водород； гидроксил, алкокси； га
