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СЕЛЕКТИВНЫЕ ИНГИБИТОРЫ НЕДИФФЕРЕНЦИРОВАННЫХ КЛЕТОК
专利权人:
ИЙСУМ РИСЁЧ ДЕВЕЛОПМЕНТ КАМПАНИ ОФ ЗЭ ХИБРУ ЮНИВЕРСИТИ ОФ ИЕРУСАЛИМ ЛТД. (IL)
发明人:
БЕН-ДАВИД Юри (IL),БЕНВЕНИСТИ Ниссим (IL),АРОРА Паял (US),ГАНЬ Цин-Фэнь (US),ГАРИППА Ральф Дж. (US)
申请号:
RU2014149559
公开号:
RU2014149559A
申请日:
2013.05.22
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. Use of a compound selected from the group consisting of: Compound of formula I Compound of formula II Compound of formula III Compound of formula IV Compound of formula V: Compound of formula VI as a cytotoxic inhibitor of undifferentiated cells, characterized in that: R is hydrogen, and R is selected from the group consisting of from hydrogen, 2,4-dioxo-5-fluoropyrimidin-1-ylcarbonyl, 2-methylbenzofuran-3-ylmethyleneamino, and-NH-R, where R is selected from the group consisting of: pyridinylcarbonyl, 2-hydroxyl-2-phenyl- 2-thiophen-2-yl-acetyl, (C) alkyl-carbo N, (N- (ethoxycarbonylmethyl) -2,4-dioxo-pyrrolidin-3-ylidene-methyl, naphthylsulfonyl and N-hydroxy-acetimidoyl, or characterized in that: R is benzoyl and R-4-chlorobenzamido and R and R are independently selected from the group consisting of hydrogen, halogen, NH, biphenyloxymethyl and (C) alkyl, that at least one of R, R, R and R is not hydrogen, halogen, NH or (C) alkyl. The use according to claim 1, characterized in that said compound has the formula I.3. The use according to claim 2, characterized in that R is hydrogen, and R is selected from the group consisting of: 2,4-dioxo-5-fluoropyrimidin-1-ylcarbonyl, 2-methylbenzofuran-3-ylmethyleneamino, and-NH-R, wherein R is selected from group consisting of: pyridinylcarbonyl, 2-hydroxyl-2-phenyl-2-thiophen-2-yl-acetyl, (C) alkylcarbonyl, N- (ethoxycarbonylmethyl) -2,4-dioxo-pyrrolidin-3-ylidene- methyl, naphthylsulfonyl and N-hydroxy-acetimidoyl, or characterized in that: R is benzoyl and R-4-chlorobenzamido and R and R are independently selected from the group consisting of hydrogen, chlorine, NH, and methyl. The use according to claim 1, characterized in that said compound has the formula II: 5. The use according to claim 1, that said compound has the formula III: 6. The use according to claim 1, different1. Применение соединения, выбранного из группы, состоящей из:соединение с формулой Iсоединение с формулой IIсоединение с формулой IIIсоединение с фо
来源网站:
中国工程科技知识中心
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