PROBLEM TO BE SOLVED: To provide medicament-containing sustained-release granules capable of preventing or reducing mutual cohesion between the sustained-release granules of the medicament, and capable of preventing or reducing adhesion to the other materials, obtained by granulating the medicament and a vehicle by using a matrix substance.SOLUTION: The medicament-containing sustained-release granules are given by coating primary granules with a water-insoluble cellulose derivative, wherein the primary granules contain the medicament and at least one of the matrix substances of a sucrose fatty acid ester and a glycerol fatty acid ester of which the both are solid at ordinary temperature.COPYRIGHT: (C)2003,JPO【課題】 マトリックス物質を用いて薬物および賦形剤を造粒して得られる薬物の徐放性顆粒の顆粒相互の凝集および他の物体への付着を防止もしくは低減する。【解決手段】 薬物と、常温で固体のショ糖脂肪酸エステルまたグリセリン脂肪酸エステルのマトリックスを少なくとも含んでいる一次顆粒に、水不溶性セルロース誘導体の被覆を施してなる薬物含有徐放性顆粒。
