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Cycloalkyl nitrilpyrazolpyridones as inhibitors of janus kinase
专利权人:
Merck Sharp & Dohme Corp.
发明人:
CHILDERS, Matthew Lloyd,DINSMORE, Christopher,FULLER, Peter,GUERIN, David,KATZ, Jason David,PU, Qinglin,SCOTT, Mark E.,THOMPSON, Christopher F.,ZHANG, Hongjun,FALCONE, Danielle,TORRES, Luis,BRUBAKER,
申请号：
ES14767371
公开号：
ES2683309T3
申请日:
2014.03.19
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula I or a pharmaceutically acceptable salt or a stereoisomer thereof: ** Formula ** A is selected from aryl and heteroaryl； n is 0, 1, 2, 3 or 4； m is 0, 1, 2, 3 or 4； p is 0, 1, 2, 3 or 4； R1 is selected from: halogen, Oxo (>； = O), C1-10 alkyl (oxy) 0-1 (carbonyl) 0-1 C0-10 alkyl, C1-10 heteroalkyl (oxy) 0-1 (carbonyl) 0-1 alkyl C0-10, C2-10 alkenyl (oxy) 0-1 (carbonyl) 0-1 C0-10 alkyl, C0-10 arylalkyl 0-1 (carbonyl) 0-1 C0-10 alkyl, C3-12 cycloalkyl 10 (oxy) 0-1 (carbonyl) 0-1 C0-10 alkyl, heteroaryl C0-10 alkyl (oxy) 0-1 (carbonyl) 0-1 C0-10 alkyl, heterocyclo (C3-12) alkyl C0-10 alkyl (oxy ) 0-1 (carbonyl) 0-1 C0-10 alkyl, C0-10 alkyl (oxy) 0-1 (carbonyl) 0-1 C0-10 aminoalkyl, (C1-10) heteroalkyl (oxy) 0-1 (carbonyl) 0 -1C0-10 aminoalkyl, C3-12 cycloalkylC0-10alkyl (oxy) 0-1 (carbonyl) 0-1aminoalkyl C0-10, arylalkylC0-10 (oxy) 0-1 (carbonyl) 0-1aminoalkyl C0-10, heteroarylalkyl C0-10 (oxy) 0-1 (carbonyl) 0-1aminalkyl C0-10, heterocycloalkyl (C3-12) alkyl C0-10 (oxy) 0-1 (carbonyl) 0-1aminoalkyl C0-10, alkylamino C0-10 ( carbonyl) 0-1 C0-10 alkyl, (C1-10) heteroalkylamino (carbonyl) 0-1 C0-10 alkyl, C3-12 cycloalkylamino (carbonyl) 0-1 C0-10 alkyl, C0-10amyl alkyl noamino (carbonyl) 0-1 C0-10 alkyl, C0-10 heteroarylalkylamino (carbonyl) 0-1C0-10 alkyl, heterocycloalkyl (C3-12) amino (carbonyl) 0-1C0-10 alkyl, C0-10 alkyl sulfonyl C0-10 alkyl , C1-10 heteroalkyl C0-10 alkyl, C0-12 cycloalkyl C0-10 alkyl sulfonyl C0-10, cycloheteroalkyl (C3-12) C0-10 alkyl sulfonylalkyl C0-10, heteroarylalkyl C0-10 sulfonylalkylC0-10 alkyl, C0-10 alkylalkyl C0-10, C1-10 alkyl sulfamoylalkyl C0-10, heteroalkyl C1-10 sulfamoylalkyl C0-10, cycloalkyl (C3-12) alkyl C0-10sulfamoylalkyl C0-10, cycloheteroalkyl (C3-12) alkyl C0-10sulfamoylalkyl C0-10, heteroarylalkyl C0 -10 Sulfamoylalkyl C0-10 alkyl, arylalkyl C0-10 sulfamoylalkyl C0-10 alkyl, C1-10 alkyl sulfonymidoylalkyl C0-10, heteroalkyl C1-10 sulfonimidoylalkyl C0-10, cycloalkyl (C3-12) alkyl C0-10 sulfonimido
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