TRABANCO-SUÁREZ ANDRÉS AVELINO,GIJSEN HENRICUS JACOBUS MARIA,PROKOPCOVÁ HANA,SURKYN MICHEL
申请号：
NZ62666212
公开号：
NZ626662A
申请日:
2012.12.04
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
The disclosure relates to 6-difluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-amine derivatives of formula (I). These work as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The disclosure also relates to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer&rsquo；s disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, cerebral amyloid angiopathy, multi-infarct dementia, Down&rsquo；s syndrome, dementia associated with stroke, dementia associated with Parkinson&rsquo；s disease and dementia associated with beta-amyloid.
