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תולדות 6–דיפלואורומתיל–6,5–דיהידרו–h2[4,1]אוקסאזין–3–אמין
专利权人:
JANSSEN PHARMACEUTICA NV
发明人:
申请号:
IL23291614
公开号:
IL232916A
申请日:
2014.06.02
申请国别(地区):
IL
年份:
2016
代理人:
摘要:
The invention relates to novel 6-difluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-amine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, cerebral amyloid angiopathy, multi-infarct dementia, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease and dementia associated with beta-amyloid.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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