Stuart Thomas Onions;William Garth Rapeport;Peter Strong;Catherine Elisab;Kazuhiro Ito;Peter John Murray;John King-Underwood;David Michel Adrien Taddei;Simon Christopher Hirst;Jonathan Gareth Williams
发明人:
Kazuhiro Ito,Peter Strong,William Garth Rapeport,Peter John Murray,John King-Underwood,Jonathan Gareth Williams,Stuart Thomas Onions,Simon Christopher Hirst,David Michel Adrien Taddei,Catherine Elisab
申请号：
US13133998
公开号：
US08299073B2
申请日:
2009.12.11
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention relates to compounds of formula (I):or a pharmaceutically acceptable salt thereof, including all stereoisomers, tautomers and isotopic derivatives thereof, which are inhibitors of p38 mitogen-activated protein kinase enzymes (referred to herein as p38 MAP kinase inhibitors), particularly the alpha and gamma kinase sub-types thereof, and their use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as COPD.
